首先，适应症横向拓展将直接放大市场规模，增厚 APL-1702 的业绩预期。APL-1702 的获批固然填补了临床中 CIN2 期的治疗空白，但 CIN1 期和 CIN3 期同样存在显著的临床需求缺口，这两大领域亦是 APL-1702 未来的核心拓展方向。
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When Anthropic CEO Dario Amodei balked at the Pentagon’s demands, warning the proposed language the DOW wanted could allow safeguards to be bypassed, Michael responded by taking the fight public. He accused Amodei of having a “God complex,” called him “a liar,” and warned that no private company should be able to dictate the military’s options. The Pentagon, he insisted, “will ALWAYS follow the law but will not yield to the desires of any profit-driven tech firm.”
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The Downtown Detention Center, as the new jail was called, had been under construction for more than three years. Once open, it would house every arrestee in Nashville. The building occupied a block near the state capitol, on a plot of land where Nashville’s old central jail had stood for thirty-five years. That jail, notoriously violent and corrupt, had symbolized the good-ol’-boy era of Nashville law enforcement, and the Downtown Detention Center was replacing it both physically and symbolically. The new jail had tablet computers for inmates and a behavioral-care center for mentally ill arrestees—the first of its kind in an American jail. The facility reflected changing attitudes toward criminal justice in Nashville, which in recent decades has become a tourism and business destination and a progressive bastion in a state sometimes called “the buckle of the Bible Belt.”